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Through a case illustration, we have demonstrated how these breakthroughs can facilitate an increased role for more personalized medicine and, thus, change the landscape of spine care.Both human and animal studies support the relationship between depression and reward processing abnormalities, giving rise to the expectation that neural signals of these processes may serve as biomarkers or mechanistic treatment targets. Given the great promise of this research line, we scrutinized those findings and the theoretical claims that underlie them. read more To achieve this, we applied the framework provided by classical work on causality as well as contemporary approaches to prediction. We identified a number of conceptual, practical, and analytical challenges to this line of research and used a preregistered meta-analysis to quantify the longitudinal associations between reward processing abnormalities and depression. We also investigated the impact of measurement error on reported data. We found that reward processing abnormalities do not reach levels that would be useful for clinical prediction, yet the available evidence does not preclude a possible causal role in depression.Plural morphology in English is associated with a multiplicity inference. For example, “Emily fed giraffes” is typically interpreted to mean that Emily fed multiple giraffes. It has long been observed that this inference disappears in downward-entailing linguistic environments, such as in the scope of negation. For example, “Emily didn’t feed giraffes” does not merely suggest that she didn’t feed multiple giraffes, but rather that she didn’t feed any. There are three main approaches to explaining this puzzle the first proposes that the plural is ambiguous, and invokes a preference for stronger meanings; the second derives multiplicity inferences as implicatures; and the third provides a homogeneity-based account. These different approaches can all account for the interpretation of the plural across upward- and downward-entailing environments. They differ, however, in what they predict for three further aspects of the plural the status of positive and negative plural sentences in singular contexts, children’s acquisition of plural meanings, and the relationship between plural meanings and scalar implicatures. In this paper, we report on three experiments investigating adults’ and preschool-aged children’s interpretation of plural morphology in English. The experiments reveal that participants distinguish positive and negative plural sentences presented in singular contexts, and that adults assign a different status to these positive and negative sentences. It is also observed that children, unlike adults, tend to accept underinformative positive plural sentences in singular contexts – in parallel with their behavior on standard scalar implicatures – while they are relatively more adult-like when it comes to negative plural sentences in the same contexts, showing a tendency to reject the negative sentences. We discuss how the findings of the three experiments are expected on a scalar implicature approach to multiplicity inferences, and the open challenges they pose for the ambiguity and homogeneity approaches.Cardiovascular disease is the leading cause of death worldwide. Conceptually, endothelial dysfunction, inflammatory conditions and oxidative stress are at the forefront of the onset and development of most cardiovascular diseases, particularly coronary artery disease and heart failure. Serum albumin has many physiological properties, including in particular antioxidant, anti-inflammatory, anticoagulant and anti-platelet aggregation activity. It also plays an essential role in the exchange of fluids across the capillary membrane. Hypoalbuminemia is a powerful prognostic marker in the general population as well as in many disease states. In the more specific context of cardiovascular disease, low serum albumin is independently associated with the development of various deleterious conditions such as coronary artery disease, heart failure, atrial fibrillation, stroke and venous thromboembolism. Low serum albumin has also emerged as a potent prognostic parameter in patients with cardiovascular disease regardless of usual prognostic markers. Remarkably, its potent prognostic value persists after adjusting for causative confounders such as malnutrition and inflammation. This prognostic value probably refers primarily to the syndrome of malnutrition-inflammation and the severity of comorbidities. Nevertheless, several recent meta-analyses strongly support the hypothesis that hypoalbuminemia may act as an unrecognized, potentially modifiable risk factor contributing to the emergence and progression of cardiovascular disease, primarily by exacerbating oxidative stress, inflammation and platelet aggregation, and by favouring peripheral congestion and pulmonary edema. Currently, it is unknown whether prevention and correction of low serum albumin offers a benefit to patients with or at risk for cardiovascular disease, and further studies are critically needed in this setting.Trans-catheter aortic valve implantation (TAVI) has recently emerged as a less invasive alternative to surgical aortic valve replacement (SAVR) in high risk patients. Although several procedures have been performed worldwide, infective endocarditis (IE) has been reported to be a rare TAVI complication, nevertheless if IE occurs it represents a life-threatening condition and treatment is challenging. TAVI-IE are thus normally treated conservatively by targeted antibiotic therapy with a high reported mortality (40%). Surgical explant represent the definitive strategy but, the intervention is at a high risk (risk of complication 87%, with an in hospital mortality of about 47%). In the present paper, we report the case of a 71-year-old patient affected by an early endocarditis after TAVI (TAVI-IE) treated at our Institution by surgical explant. The case highlights a paradox if TAVI procedures are indicated over traditional surgical valve replacement in treatment of high surgical risk patients, what should be the best management when TAVI-IE occurs in these same population of patients?