Activiteit

Although erenumab has demonstrated significant reduction in migraine frequency and improved quality of life in studies lasting 3 to 12months, little is known about long-term therapy.

This study was an open-label, 5-year treatment phase following a 12-week, double-blind, placebo-controlled trial in adults with episodic migraine. Patients initially received open-label erenumab 70mg, which increased to 140mg following a protocol amendment. Efficacy analyses included change from baseline in monthly migraine days (MMDs), monthly acute migraine-specific medication (AMSM) days, and health-related quality of life.

Of 383 patients enrolled, 250 switched to 140mg; 215 (56.1%) completed open-label treatment. Mean (standard error) change in MMDs from baseline of 8.7 (0.2) days was -5.3 (0.3) days; an average reduction of 62.3% at year 5. Among patients using AMSM at baseline (6.3 [2.8] treatment days), mean change in monthly AMSM days was -4.4 (0.3) days at the end of 5years. Patient-reported outcomes indicated stable improvements in disability, headache impact, and migraine-specific quality of life. Exposure-adjusted patient incidence rates of adverse events (AEs) were 123.0/100 patient-years; AEs were most frequently nasopharyngitis, upper respiratory tract infection, and influenza. Serious AEs (SAEs) reported by 49 patients (3.8/100 patient-years) were mostly single occurrence. Two fatal adverse events were reported. There were no increases in incidence of AEs, SAEs, or AEs leading to treatment discontinuation over 5years of exposure.

Treatment with erenumab was associated with reductions in migraine frequency and improvements in health-related quality of life that were maintained for at least 5years. No new safety signals were observed.

Treatment with erenumab was associated with reductions in migraine frequency and improvements in health-related quality of life that were maintained for at least 5 years. No new safety signals were observed.

This study aims to investigate the relationship between stress-coping strategies of individuals with chronic diseases and their self-efficacy.

Self-efficacy and coping with stress in chronic diseases affect the course of the disease.

The sample of this methodological study consisted of 178 patients who were hospitalised in a university hospital between November 2017 and November 2018.

Data were collected by the face-to-face interview method using a Patient Information Form, Stress-Coping Styles Scale and Self-Efficacy Scale. This study followed STROBE checklist for cross-sectional studies.

The study found that there was a strong relationship between patients’ coping strategies and their self-efficacies and that the variables that predict self-efficacy in order of importance were self-confident approach (β=.41), the helpless approach (β=-0.24) and the submissive approach (β=-0.15), respectively. The study also found that the optimistic approach and the seeking social support approach had no significant contribution to the model.

The most important predictor of self-efficacy in individuals with chronic disease was the self-confident approach, which was one of the problem-oriented coping strategies. Therefore, patients should be taught to use effective methods to cope with stress to increase their self-efficacy, and their self-confidence should be supported.

In individuals with chronic disease, self-efficacy has an important role to get better psycho-social adaptation. To determine patients’ self-efficacy levels and predictors will guide nursing initiatives.

In individuals with chronic disease, self-efficacy has an important role to get better psycho-social adaptation. To determine patients’ self-efficacy levels and predictors will guide nursing initiatives.The reaction of the organometallic diarsene complex [Cp2 Mo2 (CO)4 (η2 -As2 )] (1) with Ag[AlOC(CF3 )3 4 ] (Ag[TEF]) yielded the AgI monomer [Ag(η2 -1)3 ][TEF] (2). This compound exhibits dynamic behavior in solution, which allows directed selective synthesis of unprecedented organometallic-organic hybrid assemblies upon its reaction with N-donor organic molecules by a stepwise pathway, which is supported by DFT calculations. Accordingly, the reaction of 2 with 2,2′-bipyrimidine (L1) yielded the dicationic molecular compound [(η2 -1)2 Ag2 (μ-L1)][TEF]2 (3) or the 1D polymer [(η2 -1)Ag(μ-L1)]n [TEF]n (4) depending on the ratio of the reactants. However, its reactions with the pyridine-based linkers 4,4′-bipyridine (L2), 1,2-bis(4-pyridyl)ethylene (L3) and 1,2-bis(4-pyridyl)ethyne (L4) allowed the formation of the 2D polymers [(η2 -1)Ag2 (μ-Lx)3 ]n [TEF]2n [Lx=L2 (5), L3 (6), L4 (7), respectively]. Additionally, this concept was extended to step-by-step one-pot reactions of 1, [Ag(CH3 CN)3 ][AlOC(CF3 )2 (CCl3 )4 ] ([Ag(CH3 CN)3 ][TEFCl ]) and linkers L2-L4 to produce the 2D polymers [(η2 -1)Ag2 (μ,Lx)3 ]n [TEFCl ]2n [Lx=L2 (8), L3 (9), L4 (10), respectively].Kelps are dominant primary producers in temperate coastal ecosystems. Large amounts of kelp biomass can be exported to the seafloor during the algal growth cycle or following storms, creating new ecological niches for the associated microbiota. Here, we investigated the bacterial community associated with the kelp Laminaria hyperborea during its accumulation and degradation on the seafloor. click here Kelp tissue, seawater and sediment were sampled during a 6-month in situ experiment simulating kelp detritus accumulation. Evaluation of the epiphytic bacterial community abundance, structure, taxonomic composition and predicted functional profiles evidenced a biphasic succession. Initially, dominant genera (Hellea, Litorimonas, Granulosicoccus) showed a rapid and drastic decrease in sequence abundance, probably outcompeted by algal polysaccharide-degraders such as Bacteroidia members which responded within 4 weeks. Acidimicrobiia, especially members of the Sva0996 marine group, colonized the degrading kelp biomass after 11 weeks. These secondary colonizers could act as opportunistic scavenger bacteria assimilating substrates exposed by early degraders. In parallel, kelp accumulation modified bacterial communities in the underlying sediment, notably favouring anaerobic taxa potentially involved in the sulfur and nitrogen cycles. Overall, this study provides insights into the bacterial degradation of algal biomass in situ, an important link in coastal trophic chains.