Activiteit

We have further shown that the regulation of ETS1 expression and nuclear localization upon glutamine starvation is controlled in a cell type-specific manner. In PA1 cells, glutamine-induced ETS1 over-expression is HIF1α-dependent, while in SKOV3, its translocation to the nucleus is regulated through the mTOR pathway. Considering all, our study suggests that glutamine plays a very significant role in migration and invasion in ovarian cancer cells and ETS1 plays a key role in inducing such oncogenic parameters.In this study, we aimed to analyze homeowners’ level of awareness and perceived risk about buffelgrass invasion in the Tucson, Arizona Wildland-Urban Interface (WUI), as well as the factors influencing their participation in buffelgrass control and fire risk mitigation efforts. Data for the study were generated through the administration of an online survey among 117 members of Home Owner Associations (HOAs) in the Tucson WUI. The results showed that the overwhelming majority of respondents were aware of buffelgrass, but their knowledge about buffelgrass control mechanisms appeared to be limited. Respondents also more frequently expressed concern about the risks posed by buffelgrass invasion to general targets, such as the Sonoran Desert ecosystem, native plants and wildlife than risks to their private property and neighborhoods. The results also showed that the level of involvement in HOAs, and leadership in HOAs had significant positive effects on homeowners’ participation in buffelgrass control efforts. Homeowners’ duration of residence also had a significant negative effect on participation in buffelgrass control efforts, suggesting that newcomers may be more involved than long-term residents. selleck chemical Similarly, the number of months respondents spent in Tucson per year had a negative effect on the number of hours spent on buffelgrass control efforts. Respondents’ perceived risk about buffelgrass invasion also had a positive effect on the hours spent on buffelgrass control as well as their level of involvement in fire risk mitigation efforts. These results highlight the importance of local institutions and community heterogeneity in social responses to threats in WUI communities. Policies aimed at building the resilience of WUI communities need to account for their complexity as coupled social-ecological systems.

Kratom is a psychoactive plant preparation originating from Southeast Asia. It has been used as a recreational and performance drug in Southeast Asia, and is now increasingly used in Europe and the U.S.

We describe the case of a 63-year-old man who presented for treatment after his long-term Kratom use failed as a self-management for persistent major depression (ICD 10 F33.2) and a generalized anxiety disorder (ICD-10 F41.1). The failure coincided with emerging stress at the beginning of the COVID-19 pandemic. The patient suffered from childhood on from ruminative thinking and depressive mood, which was treated in several settings during his life. He started to use alcohol to control his depression, but developed an alcohol addiction. This was successfully treated and the patient remained abstinent for more than 25 years afterwards. About 7 years ago, he started to use Kratom 3-4 times daily on a regular, but constant rate. Kratom use worked efficiently as a self-management of his depression with no escaland addiction, but may be limited by a temporary increase in psychological stress load and a relapse into major depression and generalized anxiety disorder.

Albinism is a genetic condition caused by a deficit in the production of the pigment called melanin, which protects the skin against ultraviolet light and provides the skin with its color production. The condition may predispose persons with albinism (PWAs) to lifelong physical and health problems, such as visual impairment and ultra-violet induced skin damage. Due to this condition, we explored the challenges faced by persons living with albinism as they socialize in Lilongwe District, Malawi.

The study adopted an interpretative phenomenological approach and included 30 participants comprising 13 females and 14 males with albinism and three key informants from Association of People with Albinism in the Lilongwe district in Malawi. Data were collected through in-depth interviews and focus group discussions. Van Manen’s (2014) six steps of phenomenological analysis was used to analyze all data.

People with albinism face a variety of problems, the most common of which are financial constraints, health complications due to a lack of adequate medical care, a lack of community support leading to stigma and discrimination, and superstitious beliefs.

People with albinism suffer socially as a result of misconceptions, behaviours, social isolation, labelling, and beliefs that are negatively correlated with their disorder. PWAs face these problems as a result of public misunderstanding about albinism.

People with albinism suffer socially as a result of misconceptions, behaviours, social isolation, labelling, and beliefs that are negatively correlated with their disorder. PWAs face these problems as a result of public misunderstanding about albinism.In this research, an unrivalled hybrid scheme which involves the coupling of the new Elzaki integral transform (an improved version of Laplace transform) and a modified differential transform called the projected differential transform (PDTM) have been implemented to solve the generalized Burgers-Fisher’s equation; which springs up due to the fusion of the Burgers’ and the Fisher’s equation; describing convective effects, diffusion transport or interaction between reaction mechanisms, traffic flows; and turbulence; consequently finding meaningful applicability in the applied sciences viz gas dynamics, fluid dynamics, turbulence theory, reaction-diffusion theory, shock-wave formation, traffic flows, financial mathematics, and so on. Using the proposed Elzaki projected differential transform method (EPDTM), a generalized exact solution (Solitary solution) in form of a Taylor multivariate series has been obtained; of which the highly nonlinear terms and derivatives handled by PDTM have been decomposed without expansion, computation of Adomian or He’s polynomials, discretization, restriction of parameters, and with less computational work whilst achieving a highly convergent results when compared to other existing analytical/exact methods in the literature, via comparison tables, 3D plots, convergence plots and fluid-like plots.