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Anemia is a worldwide public health problem and also associated with Helicobacter pylori (H. pylori) infection. Determining the association of anemia with H. pylori infection is important to develop evidence-based decision and intervention strategies, which is not well known in Ethiopia. Thus, this study aimed to determine the association between anemia and H. pylori infection among adult dyspeptic patients attending Wachemo University Nigist Eleni Mohammad Memorial Referral Hospital in Southwest Ethiopia.

A cross-sectional study was conducted from January to April 2019 involving 362 consecutive adult dyspeptic patients who came to the hospital during the study period. Socio-demographic, clinical and other related data were collected by structured questionnaires. Four milliliters of the venous blood sample was collected for hematological parameters analysis and blood film preparation. A stool sample was collected to detect H. pylori antigen and intestinal parasites. Data were analyzed by SPSS version 21. associated with anemia. The findings of this study should be taken into account for the prevention and control of anemia among dyspeptic adults.Several sinogram inpainting based metal artifact reduction (MAR) methods have been proposed to reduce metal artifact in CT imaging. The sinogram inpainting method treats metal trace regions as missing data and estimates the missing information. However, a general assumption with these methods is that data truncation does not occur and that all metal objects still reside within the field-of-view (FOV). These assumptions are usually violated when the FOV is smaller than the object. Thus, existing inpainting based MAR methods are not effective. In this paper, we propose a new MAR method to effectively reduce metal artifact in the presence of data truncation. The main principle of the proposed method involves using a newly synthesized sinogram instead of the originally measured sinogram. The initial reconstruction step involves obtaining a small FOV image with the truncation artifact removed. The final step is to conduct sinogram inpainting based MAR methods, i.e., linear and normalized MAR methods, on the synthesized sinogram from the previous step. The proposed method was verified for extended cardiac-torso simulations, clinical data, and experimental data, and its performance was quantitatively compared with those of previous methods (i.e., linear and normalized MAR methods directly applied to the originally measured sinogram data). The effectiveness of the proposed method was further demonstrated by reducing the residual metal artifact that were present in the reconstructed images obtained using the previous method.The Na+/K+ ATPase is a key regulator of the hepatocytes ionic homeostasis, which when altered may lead to many liver disorders. We demonstrated recently, a significant stimulation of the Na+/K+ ATPase in HepG2 cells treated with the S1P analogue FTY 720P, that was mediated through PGE2. The mechanism by which the prostaglandin exerts its effect was not investigated, and is the focus of this work. The type of receptors involved was determined using pharmacological inhibitors, while western blot analysis, fluorescence imaging of GFP-tagged Na+/K+ ATPase, and time-lapse imaging on live cells were used to detect changes in membrane abundance of the Na+/K+ ATPase. The activity of the ATPase was assayed by measuring the amount of inorganic phosphate liberated in the presence and absence of ouabain. The enhanced activity of the ATPase was not observed when EP4 receptors were blocked but still appeared in presence inhibitors of EP1, EP2 and EP3 receptors. The involvement of EP4 was confirmed by the stimulation observed with EP4 agonist. The stimulatory effect of PGE2 did not appear in presence of Rp-cAMP, an inhibitor of PKA, and was imitated by db-cAMP, a PKA activator. Chelating intracellular calcium with BAPTA-AM abrogated the effect of db-cAMP as well as that of PGE2, but PGE2 treatment in a calcium-free PBS medium did not, suggesting an involvement of intracellular calcium, that was confirmed by the results obtained with 2-APB treatment. Live cell imaging showed movement of GFP-Na+/K+ ATPase-positive vesicles to the membrane and increased abundance of the ATPase at the membrane after PGE2 treatment. It was concluded that PGE2 acts via EP4, PKA, and intracellular calcium.Inconel 718 alloy is widely used in aero-engines and high-temperature environments. However, residual stress caused by processing and molding leads to an uneven distribution of internal pressure, which reduces the reliability of service process. Therefore, numerical simulation of the nanoindentation process was applied to evaluate the effect of residual stress on the machined subsurface of Inconel 718. A gradient material model of Inconel 718 was established in ABAQUS finite element software. Mechanical properties based on nanoindentation testing showed an influence of residual stress in combination with indenter geometry. The orthogonal experimental results show that under diverse residual stress states, the indenter’s geometry can affect the pile-up of the material surface after nanoindentation and significantly influence the test results. With increases in piling-up, the error caused by residual stress on the characterization of the mechanical properties of the hardened layer increases. Through the establishment of a numerical model, the influence of residual stress can be predicted within nanoindentation depths of 300 nm.The main goal of the current paper is to contribute to the existing literature of probability distributions. anti-PD-1 antibody inhibitor In this paper, a new probability distribution is generated by using the Alpha Power Family of distributions with the aim to model the data with non-monotonic failure rates and provides a better fit. The proposed distribution is called Alpha Power Exponentiated Inverse Rayleigh or in short APEIR distribution. Various statistical properties have been investigated including they are the order statistics, moments, residual life function, mean waiting time, quantiles, entropy, and stress-strength parameter. To estimate the parameters of the proposed distribution, the maximum likelihood method is employed. It has been proved theoretically that the proposed distribution provides a better fit to the data with monotonic as well as non-monotonic hazard rate shapes. Moreover, two real data sets are used to evaluate the significance and flexibility of the proposed distribution as compared to other probability distributions.