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The patient was asymptomatic after 4-weeks, with endoscopic healing and renal function stabilization. GI involvement limited to the duodenum in the setting of ANCA-MPO vasculitis is a rare condition. Moreover, histopathologic confirmation of vasculitis in endoscopic biopsy samples is exceptional.We present the case of a 55-year-old male that was admitted to our hospital for cholestatic hepatitis. Other causes of hepatitis were excluded with imaging, laboratory and serologic tests. A liver biopsy was performed, which was compatible with toxicity-induced hepatitis. Re-assessing the patient, he mentioned the start of treatment with candesartan cilexetil 3 weeks prior to the onset of the symptoms. Candesartan was withdrawn, with a progressive improvement in cholestasis and complete normalization of liver biochemistry at 6 months. The patient was diagnosed with candesartan-induced cholestatic hepatitis, probable according to CIOMS/RUCAM scale.Forty-eight year old man with epigastric pain. CT scan shows a common hepatic artery aneurysm (HAA) of 4,6 cm in size with permeable portal vein. Angiography demonstrates that it affects from the beginning of the celiac trunk until hepatic arteries bifurcation, producing a proximal splenic artery stenosis. selleck Proximal and distal embolization is done achieving a complete aneurysm occlusion. A stent is placed in celiac trunk in order to maintain splenic flow. Permeability of distal hepatic artery through choledochal arteries is observed in a month follow-up CT scan. HAA are infrequent but potentially lethal. Endovascular techniques should be considered of choice currently. HAA embolization has an elevated risk of hepatic ischemia.Intestinal intussusception is a condition usually observed in pediatric patients and is rare in adults. It has been described as idiopathic or secondary to several etiologies. Intussusception occurring in the large bowel is more likely to have a malignant etiology. Abdominal computed tomography is the normal diagnostic modality. Colonoscopy may be helpful to distinguish benign from malignant lesions, prior to deciding an appropriate management. An endoscopy approach can be attempted in patients in whom a benign mass is suspected. However, surgery remains the mainstay in adult intussusception, especially when a malignant etiology cannot be ruled out. We present a rare case of colo-colonic intestinal intussusception in an adult diagnosed by outpatient colonoscopy, which is an uncommon way to discover this entity.The portal venous aneurysm(PVA) is a very rare entity, which can be congenital or acquired (if portal hypertension, cirrhosis, pancreatitis, surgical history). Although the discussion is still ongoing, treatment would be indicated in symptomatic PVA, over 30mm or progressive growth. In order to provide an update on the subject due to the low incidence of this finding, we present the case of a 51-year-old woman who comes to the ER for painful obstructive jaundice; the ultrasound shows the presence of cholelitiasis and choledicolitiasis and identifies a nodular image in continuity with the right portal branch of 25x22x21 mm. This dilation is confirmed by MRI. After committee evaluation, follow-up was decided and to reserve the possibility of embolization if growth or symptomatology appeared.Natural photosynthesis relies on a sophisticated charge transfer pathway among multiple components with precise spatial, energetic, and temporal organizations in the aqueous environment. It continues to inspire and challenge the design and fabrication of artificial multicomponent colloidal nanostructures for solar-to-fuel conversion. Herein, we introduce a plasmonic photocatalyst synthesized with colloidal methods with five integrated components including cocatalysts installed in orthogonal locations. The precise deposition of individual inorganic components on an Au/TiO2 nanodumbell nanostructure is enabled by photoreduction and photo-oxidation, which selectively occurs at the TiO2 tip sites and Au lateral sites, respectively. Under visible-light irradiation, the photocatalyst exhibited activity of oxygen evolution from water without scavengers. We demonstrate that each component is essential for improving the photocatalytic performance. In addition, mechanistic studies suggest that the photocatalytic reaction requires combining the hot charge carriers derived from exciting both the d-sp interband transition and the localized surface plasmon resonance of Au.Nanoparticle (NP)-mediated therapies are promising tools for the treatment of a wide range of diseases, including stroke and cancer, due to the outstanding performance they have shown for specifically targeting diseased sites. Importantly, the coupling of stiffness and shape of NPs has a significant influence on transportation via blood flow and internalization by targeted cells. Nevertheless, the underlying mechanism of this coupling effect on the endocytosis of NPs remains largely unexplored, resulting from a lack of clear measurement of stiffness for NPs in experiments, as well as the complexity of the endocytosis process. To overcome the above challenges, coarse-grained simulations, which can provide abundant nanoscale details and precise control of mechanical properties of NPs, were implemented to study the stiffness and shape dependence of the endocytosis of spherocylindrical NPs. To understand the coupling effect between shape and stiffness of NPs for membrane wrapping, coarse-grained molecular dynamicrespect to geometry and particle stiffness, providing a useful guideline for designs of nanoparticles that can be implemented in next-generation nanoparticle-assisted therapy.The first total synthesis of four naturally occurring dihydro-β-agarofuran esters has been accomplished via a highly stereocontrolled 14-step access to their common core triol, (-)-isocelorbicol. A semipinacol rearrangement of an epoxy alcohol to install a quaternary carbon, diastereoselective conjugate reduction of a spirocyclic butenolide for the establishment of a methyl-bearing chiral center, and ring-closing metathesis to construct the decalin ring system were exploited as the key steps for the high-yielding synthesis of (-)-isocelorbicol.