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We investigated changes in the cranial/cephalic index of the Korean population in millennia, centuries, and recent decades. Secular changes of Korean’s cephalic index in history were studied using the data of archaeology literature and our measurement data of different adult skull sets for the fifteenth-nineteenth century Joseon people, the Korean War victims (1950-1953), and the Korean skeletons collected by medical schools in the 1960s. A change in head shape during the last century was also estimated by the analysis on Korean cephalometric datasets of Korean Research Institute of Standards and Science. In brief, over the past 2000 years, the crania of Korean people have steadily changed from mesocephalic to brachycephalic, mainly due to the cranial length shortening. Brachycephalization accelerated at the beginning of the twentieth century and continued until the early twenty-first century, largely caused by increased cephalic breadth. We also note that debrachycephalization began in birth cohorts around 1965 for males and around 1970 for females. Taken together, we figure out that the head shape of Korean people has been gradually shortened over millennia and then has undergone dramatic shortening in the last century. In recent decades, however, the changing pattern has reversed to debrachycephalization, for which we discussed about the possible causes in the present report.Since more and more elderly people suffer from lower extremity movement problems, it is of great social significance to assist persons with motor dysfunction to walk independently again and reduce the burden on caregivers. The self-paced walking intention, which could increase the ability of self-control on the start and stop of motion, was studied by applying brain-computer interface (BCI) technology, a novel research field. The cerebral hemoglobin signal, which was obtained from 30 subjects by applying functional near-infrared spectroscopy (fNIRS) technology, was processed to detect self-paced walking intention in this paper. Teager-Kaiser energy was extracted at each sampling point for five sub-bands (0.0095~0.021 Hz, 0.021~0.052 Hz, 0.052~0.145 Hz, 0.145~0.6 Hz, and 0.6~2.0 Hz). Gradient boosting decision tree (GBDT) was then utilized to establish the detecting model in real-time. The proposed method had a good performance to detect the walking intention and passed the pseudo-online test with a true positive rate of 100% (80/80), a false positive rate of 2.91% (4822/165171), and a detection latency of 0.39 ± 1.06 s. GBDT method had an area under the curve value of 0.944 and was 0.125 (p  less then  0.001) higher than linear discriminant analysis (LDA). The results reflected that it is feasible to decode self-paced walking intention by applying fNIRS technology. This study lays a foundation for applying fNIRS-based BCI technology to control walking assistive devices practically. Graphical abstract Graphical representation of the detecting process for pseudo-online test. The lower figure is a partial enlargement of the upper figure. In the lower figure, the blue line represents the probability of walking predicted by GBDT without smoothing and the orange-red line represents the smoothed probability. The dark-red ellipse shows the effect of the smoothing-threshold method.PURPOSE Neuroinflammation in Parkinson’s disease (PD) is known to play a pivotal role in progression to neuronal degeneration. It has been reported that colony-stimulation factor 1 receptor (CSF-1R) inhibition can effectively deplete microglia. However, its therapeutic efficacy in PD is unclear still now. PROCEDURES To elucidate this issue, we examined the contribution of microglial depletion to PD by behavioral testing, positron emission tomography (PET) imaging, and immunoassays in sham, PD, and microglial depletion PD model (PLX3397 was administered to PD groups, with n = 6 in each group). RESULTS The microglial depletion in PD model showed improved sensory motor function and depressive-like behavior. NeuroPET revealed that PLX3397 treatment resulted in partial recovery of striatal neuro-inflammatory functions (binding values of [18F]DPA-174 for PD, 1.47 ± 0.12, p  0.05). Western blotting for microglia showed similar changes. 5-FU research buy CONCLUSION Microglial depletion has inflammation-related therapeutic effects, which have beneficial effects on motor and nonmotor symptoms of PD.PURPOSE Current response assessment systems for cancer patients receiving immunotherapy are limited. This is due to the associated inflammatory response that may confound the conventional morphological response evaluation criteria in solid tumors and metabolic positron emission tomography (PET) response criteria in solid. Recently, novel PET imaging techniques using radiolabeled antibodies and fragments have emerged as a particularly sensitive and specific modality for quantitative tracking of immune cell dynamics. Therefore, we sought to investigate the utility of Cu-64 labeled F(ab)’2 fragments for in vivo detection of CD8a+ T cells as a prognostic imaging biomarker of response to immunotherapy in an immunocompetent mouse model of colorectal cancer. PROCEDURES [64Cu]NOTA-CD8a was produced by enzymatic digestion of rat-anti-mouse CD8a antibody (clone YTS169.4), purified yielding isolated CD8a-F(ab)’2 fragments and randomly conjugated with the 2-S-(isothiocyanatbenzyl)-1,4,7-triazacyclononane-1,4,7-triacetic mor volume among mice. CONCLUSION In the present study, we demonstrated that [64Cu]NOTA-CD8a was able to detect treatment-induced changes in CD8a+ infiltration in murine CT26 colon tumors following a common preclinical combination treatment protocol. Overall, [64Cu]NOTA-CD8a exhibited good prognostic and predictive value. We suggest that [64Cu]NOTA-CD8a PET imaging can be used as an early biomarker of response to therapy in preclinical models.To further promote the clinical application of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) in infection and inflammation and standardize the diagnostic process, the experts in relevant fields in China carried out discussion and formed the Expert Consensus on the clinical application of FDG PET/CT in infection and inflammation. This consensus is intended to provide a reference for imaging physicians to select a reasonable diagnostic plan. However, it should be noted that it couldn’t include or solve all the problems in clinical operation. Imaging physicians and technicians should develop a comprehensive and reasonable diagnostic procedure according to their professional knowledge, clinical experience and currently available medical resources when facing specific patients.