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9% (n = 124) of cases only experienced coercive measures within these first 24 h and were not subjected to any coercive measures after. These results show that certain patient characteristics put individuals at higher risk of being secluded or restrained and that the risk of experiencing coercive measures is highest at the time during and shortly after emergency admission. To prevent coercive measures, it is crucial to target more resources and put in place measures specifically tailored to these emergency situations and the most vulnerable patient groups.This study evaluated the effect of endocrown and ferrule restorative treatment on the mechanical behavior of anterior endodontically treated teeth. Human canines were treated endodontically and distributed in five groups (n = 10) sound teeth (S), crown associated with glass fiber post (GFP) and ferrule (GFPf+) and that without ferrule (GFPf-), and endocrown with ferrule (Ef+) and that without ferrule (Ef-). The crowns were obtained in lithium disilicate-based glass ceramic and cemented with resin. Thermomechanical loading (TL) was performed with progressive load of 80, 120, 160, 200, 240, 280, and 320 N with 20,000 cycles each, 140,000 cycles in total, frequency of 5 Hz, and temperature variation of 5°C-55 °C, followed by fracture resistance testing with load cell of 1000 Kgf and crosshead speed of 0.5 mm/min in a universal testing machine. Failure mode has been evaluated. Data were compared by Kaplan-Meier survival analysis (p less then 0.05) for TL and one-way ANOVA and Tukey’s test (p less then 0.05) for fracture resistance. TL showed higher number of fractures for groups without ferrule (GFPf- = 7, GFPf+ = 3, Ef- = 10, and Ef+ = 2) and lower mean fracture load probability (GFPf+ = 300 N, GFPf- = 280 N, Ef+ = 320 N, Ef- = 188 N) than those with ferrule. Regarding fracture, teeth rehabilitated with GFP were more resistant to endocrowns with ferrule (p less then 0.05). A higher percentage of type III failures after fatigue and type II failures after fracture were found. In conclusion, rehabilitation using GFP with ferrule is more favorable for anterior teeth, but the use of endocrown with ferrule proved feasible.Porous fusion cage is considered as a satisfactory substitute for solid fusion cage in transforaminal lumbar interbody fusion (TLIF) surgery due to its interconnectivity for bone ingrowth and appropriate stiffness reducing the risk of cage subsidence and stress shielding. This study presents an integrated global-local topology optimization approach to obtain porous titanium (Ti) fusion cage with desired biomechanical properties. Local topology optimizations are first conducted to obtain unit cells, and the numerical homogenization method is used to quantified the mechanical properties of unit cells. The preferred porous structure is then fabricated using selective laser melting, and its mechanical property is further verified via compression tests and numerical simulation. Afterward, global topology optimization is used for the global layout. The porous fusion cage obtained by the Boolean intersection between global structural layout and the porous structure decreases the solid volume of the cage by 9% for packing more bone grafts while achieving the same stiffness to conventional porous fusion cage. To eliminate stress concentration in the thin-wall structure, framework structures are constructed on the porous fusion cage. Although the alleviation of cage subsidence and stress shielding is decelerated, peak stress on the cage is significantly decreased, and more even stress distribution is demonstrated in the reinforced porous fusion cage. It promises long-term integrity and functions of the fusion cage. Overall, the reinforced porous fusion cage achieves a favorable mechanical performance and is a promising candidate for fusion surgery. The proposed optimization approach is promising for fusion cage design and can be extended to other orthopedic implant designs.

Access to safe sanitation and the elimination of open defecation are pre-conditions for improved child health and nutrition and wider achievement of the Sustainable Development Goals (SDGs). While Indonesia has a solid policy framework, the country ranks third globally in terms of numbers of people practicing open defecation.

Our aim was to assess the effectiveness of a five-year strategy to reduce open defecation through accelerating implementation of the national sanitation program across districts receiving variable levels of external support.

Among three provinces with poor sanitation program performance, districts were selected to receive one of three levels of external support. High intensity districts (n=6) benefitted from enabling environment strengthening support including political and social mobilization, direct capacity development, and efforts to strengthen planning, budgeting, monitoring and supervision; learning districts (n=16) benefitted from cross-district learning opportunities and poent sanitation programming in Indonesia can yield substantial improvements in outcomes in a relatively short period of time.

Efforts to strengthen provincial and district government capacity to implement sanitation programming in Indonesia can yield substantial improvements in outcomes in a relatively short period of time.The C-X-C motif ligand 8 and C-X-C chemokine receptor 2 (CXCL8-CXCR2) axis is involved in pathogenesis of various diseases including inflammation and cancers. Various CXCR2 antagonists are under development for several diseases. Our previous high-throughput cell-based assay specific for CXCR2 has identified a pyrimidine-based compound CX797 acting on CXCR2 down-stream signaling. A lead optimization campaign through scaffold-hopping strategy led to a series of 2-thioureidothiophene-3-carboxylates (TUTP) as novel CXCR2 antagonists. learn more Structure-activity relationship study of TUTPs led to the identification of compound 52 that significantly inhibited CXCR2-mediated β-arrestin recruitment signaling (IC50 = 1.1±0.01 μM) with negligible effect on CXCL8-mediated cAMP signaling and calcium flux. Similar to the known CXCR2 antagonist SB265610, compound 52 inhibited CXCL8-CXCR2 induced phosphorylation of ERK1/2. TUTP compounds also inhibited CXCL8-mediated cell migration and showed synergy with doxorubicin in ovarian cancer cells, thereby supporting TUTPs as promising compounds for cancer treatment.