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sign, delivery, and cost-effectiveness of BCC screening interventions for rural communities. Future research might focus on methods to promote repeat BCC screening and effective translation of these interventions for other rural populations.

Barrett’s esophagus (BE) is a precursor of esophageal adenocarcinoma (EAC). Therefore, an accurate diagnosis of BE is important for the subsequent follow-up and early detection of EAC. However, the definitions of BE have not been standardized worldwide; columnar-lined epithelium (CLE) without intestinal metaplasia (IM) and/or < 1cm is not diagnosed as BE in most countries. This study aimed to clarify the malignant potential of CLE without IM and/or < 1cm genetically.

A total of 96 consecutive patients (including nine patients with EAC) who had CLE were examined. Biopsies for CLE were conducted, and patients were divided into those with IM and > 1cm (Group A) and those without IM and/or < 1cm (Group B). Malignant potential was assessed using immunochemical staining for p53. Moreover, causative genes were examined using next-generation sequencing (NGS) on ten patients without Helicobacter pylori infection and without atrophic gastritis.

Of the 96 patients, 66 were in Group B. The proportion of carcinoma/dysplasia in Group A was significantly higher than that in Group B (26.7% in Group A and 1.5% in Group B; p < 0.01). However, one EAC patient was found in Group B. In the immunostaining study for non-EAC patients, an abnormal expression of p53 was not observed in Group A, whereas p53 loss was observed in three patients (4.6%) in Group B. In the NGS study, a TP53 mutation was found in Group B.

CLE without IM and/or < 1cm has malignant potential. This result suggests that patients with CLE as well as BE need follow-up.

CLE without IM and/or less then  1 cm has malignant potential. This result suggests that patients with CLE as well as BE need follow-up.This study aims to investigate the fine structure of the different cell types in the central brain of Eledone cirrhosa; the organelles in the neurons and the glial cells; the glial hemolymph-brain barrier; the neuro-secretions and the relationships between glial and nerve cells. The brain is surrounded by a non-cellular neurilemma followed by a single layer of perilemmal cells. Ependymal cells, highly prismatic glial cells, astrocytes, oligodendrocytes and epithelial processes were observed. The perikarya of the neurons are filled with slightly oval nuclei with heterochromatin, a strongly tortuous ER, numerous mitochondria and Golgi apparatus with two types of vesicles. In the cellular cortex, glial cells are much less numerous than the neurons and they are located preferably at the border between perikarya and neuropil. Furthermore, they send many branching shoots between the surrounding neuron perikarya and the axons. The glial cytoplasmic matrix appears more electrodense than that of the neurons. Only few ribosomes are attached to the membranes of the ER; the vast majorities are free. In the perikarya of the glial cells, mitochondria, multi-vesicular bodies, various vacuoles and vesicles are present. The essential elements of the hemolymph-brain barrier are the endothelial cells with their tight junctions. The cytoplasm contains various vesicles and mitochondria. However, two other cell types are present, the pericytes and the astrocytes, which are of great importance for the function of the hemolymph-brain barrier. The cell-cell interactions between endothelial cells, pericytes and astrocytes are as close as no other cells.

Rheumatic diseases are a reason for frequent consultation with primary care doctors. Unfortunately, there is a high percentage of misdiagnosis.

To design an algorithm to be used by primary care physicians to improve the diagnostic approach of the patient with joint pain, and thus improve the diagnostic capacity in four rheumatic diseases.

Based on the information obtained from a literature review, we identified the main symptoms, signs, and paraclinical tests related to the diagnosis of rheumatoid arthritis, spondyloarthritis with peripheral involvement, systemic lupus erythematosus with joint involvement, and osteoarthritis. We conducted 3 consultations with a group of expert rheumatologists, using the Delphi technique, to design a diagnostic algorithm that has as a starting point “joint pain” as a common symptom for the four diseases.

Thirty-nine rheumatologists from 18 countries of Ibero-America participated in the Delphi exercise. In the first consultation, we presented 94 items to the experts (35linical tests requested by primary care physicians, in the management of patients with joint pain. This point was verified in a recently published study in the journal Rheumatology International (reference number 31).Commercial demand is the prerequisite for the expansion of rubber plantation, which is highly dependent on climate, topography, and soil factors. Without the contextual knowledge on these factors, the expansion of rubber plantation would remain unproductive. KRIBB11 This study thereby aimed to evaluate the current and future suitable habitat distributions of rubber using maximum entropy (MaxEnt) species distribution model in Xishuangbanna, Southwest China. A total of 148 field-based presence locations and environmental variables (soil, bioclimatic, topography, and land use) were used to predict the suitable areas of rubber plantations using HadGEM2-ES climate model. Medium and high climatic representative concentration pathways (RCPs) (4.5 and 8.5) were selected to predict the suitable habitats for the years 2050 and 2070. Among various factors, annual mean temperature, annual precipitation, precipitation of wettest month, precipitation seasonality, precipitation of warmest quarter, and soil exchangeable H+ contributed significantly to the distribution of rubber. Currently, 1119 km2 and 2716 km2 were predicted as high and moderately suitable areas respectively. It is predicted with increase rates in the high suitable areas, 49.96% and 328.95% by 2050 and 2070 respectively under RCP 4.5. This result indicates that the medium climate change of RCP 4.5 may have a direct positive effect on the expansion of habitat suitability of rubber. We also found potential areas for rubber cultivation in Jinghong and Mengla townships, where the further expansion is anticipated with desirable land-use planning by conserving reserve forest and native vegetation.