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The incidence increases with age, especially from the age of 50-54 years (41% increase over the 45-49 age group) and is always higher in women. The global HR was 6.75/100,000 and 15.7/100,000 in persons aged 50 and over; HR increases with age, especially from 60-64 years onwards (50% increase over 54-59 age group) and is always higher in men. The 68.8% of cases and 80.2% of hospitalisations for HZ occurred from the age of 50.

In Spain HZ is a frequent and severe entity in adults and elderly people requiring public health interventions. The demographic changes and the introduction of vaccination require continued monitoring of HZ behaviour in terms of incidence and severity.

In Spain HZ is a frequent and severe entity in adults and elderly people requiring public health interventions. The demographic changes and the introduction of vaccination require continued monitoring of HZ behaviour in terms of incidence and severity.BACKGROUND The number of pregnancies and interval between pregnancies can have significant impact on a woman’s reproductive, psychological, and general health. Exposure to multiple reproductive losses is especially associated with higher rates of negative outcomes. MATERIAL AND METHODS Medical records from 1999-2012 for all Medicaid beneficiaries born after 1982 in the 17 states that provide coverage for all reproductive services (N=2 162 600) were examined to identify the timing of subsequent pregnancies and their outcomes within 3 years of a first known pregnancy. RESULTS One year after their first pregnancy outcomes, 22.6%, 17.8%, and 11.7% of women who had an induced abortion, a natural loss, or a birth, respectively, conceived at least 1 additional pregnancy. By the second year, the percentage of repeat pregnancies rose to 37.5% after an abortion, 25.6% after a natural loss, and 23.1% after a birth. Graphing the weekly conception rates revealed that women who had abortions and natural losses showed similar patterns of rapid repeat pregnancy, with the rate of second conception spiking quickly within 3 to 4 months after the first pregnancy outcome. CONCLUSIONS These findings support the clinical evidence that pregnancy loss may contribute to rapid repeat pregnancies and may better inform interventions to reduce rapid repeat pregnancies.BACKGROUND Left ventricular thrombus (LVT) is a complication of left ventricular dysfunction and myocardial infarction (MI) and is associated with systemic thromboembolism. Two-dimensional transthoracic echocardiography (TTE) is considered the first-line diagnostic tool for detection of LVT. find more Vitamin K antagonists (VKA) targeting an international normalized ratio (INR) from 2 to 3 are the only approved treatments by the Food and Drug Administration (FDA). New emerging observational data support the use of direct oral anticoagulants (DOACs) as an alternative therapeutic option; however, their safety and efficacy have not been assessed in a good-quality randomized controlled trial. CASE REPORT Here, we present a case of a 43-year-old man diagnosed with human immunodeficiency virus (HIV)-associated dilated cardiomyopathy complicated with an LVT. He was treated with rivaroxaban for 9 consecutive months with no interruption of therapy at any point in time; however, he presented to the emergency department with symptoms of decompensated heart failure. A follow-up TTE demonstrated a significant increase in the size of his LVT. This case questions the efficacy of using factor Xa inhibitor (rivaroxaban) as an alternative option for LVT treatment. CONCLUSIONS This case demonstrates a failure of rivaroxaban in treating LVT in a patient with HIV-associated dilated cardiomyopathy. Good-quality randomized clinical trials or prospective studies are required to establish the efficacy and safety of DOACs for LVT treatment as an alternative to VKA.Energy metabolism is a critical factor that influences disease pathogenesis. Recent high-throughput genomic studies have enabled us to look into disease biology with greater details. Celiac disease (CD) is an inflammatory autoimmune disease where ~60 non-HLA genes were identified which in conjunction with HLA genes explain ~55% of the disease heritability. In this study we aimed to identify susceptibility energy metabolism genes and investigate their role in CD. We re-analysed published Immunochip genotyping data, which were originally analysed for CD association studies in north Indian and Dutch population. 269 energy metabolism genes were tested. Meta-analysis was done for the identified SNPs. To validate the functional implications of identified markers and/or genes, in silico functional annotation was performed. Six SNPs were identified in north Indians, of which three markers from two loci were replicated in Dutch. rs2071592 (PMeta=5.01e-75) and rs2251824 (PMeta=1.87e-14) from ATP6V1G2-NFKBIL1-DDX39B locus and rs4947331 (PMeta= 9.85e-13) from NEU1 locus were found significantly associated. Identified genes are key regulators of cellular energy metabolism and associated with several immune mediated diseases. In silico functional annotation showed significant biological relevance of these novel markers and genes. FDI approved therapeutics against ATP6V1G2 and NEU1 are currently in use to treat chronic and inflammatory diseases. This study identified two pathogenic loci, originally involved in energy metabolism. Extensive investigation showed their synergistic role in CD pathogenesis by promoting immune mediated enteric inflammation. Proposed CD pathogenesis model in this study needs to be tested through tissue-on-chip and in vivo methods to ensure its translational application.The whitefly Bemisia tabaci (Gennadius) is a devastating polyphagous pest that causes significant losses in several economically important crops worldwide. Although chemical control is the fastest management strategy, insecticide resistance development poses a greater constraint in whitefly management. In this study, we used RNA interference (RNAi) technique to understand the role of target of rapamycin (TOR) gene in whitefly. In insects, TOR plays a crucial role in cell growth, metabolism, proliferation, and reproduction. Although sequence analyses of TOR revealed 95 nucleotides different in TOR gene sequence compared to predicted sequence (GenBank accession no. XM019060193.1), but this led to synthesis of only two different amino acids at positions 1448 and 1768. Phylogenetic analysis of amino acid sequence revealed that TOR gene of B. tabaci, Acrythosiphum pisum and Nilaparvata lugens were more closely related to each other and were clustered together. Oral feeding of artificial diet containing dsRNA viz 2.